Xi Huang
Nanjing University of Chinese Medicine, China
Title: Shugan clue us to the discovery of shared molecules that mediate anti-depression and prokinetic in stressed rat
Biography
Biography: Xi Huang
Abstract
The unique challenge of DCWFD (depressive comorbidity with functional dyspepsia, FD) is its unitied theory including shared pathogenesis and therapeutic strategy. The latter inhibition to gut motor by SSRIs result in anti-depressive discontinuance. Surprisedly, Shugan, one of TCM strategies against DCWFD, has been being neglected during past 2200 years until the discovery of its anti-depression and prokinetic (A&P) in 2011. Here, Shugan-treated target is Ganyupixu (ancient disease name of TCM) similar to DCWFD in symptoms. Clinically and experimently it also has been comprehensively and seperately applied in the treatment of depression, FD and DCWFD. From above clues, we advance the hypothesis involed in simultaneous A&P against stress. The evidences for testing hypothesis in stressed rats include: i.simultaneous A&P activities by 7 agents including TCM Chaihu-Shugan-San (it contains 6 herbs of fructus aurantii,et al), fructus aurantii and the related 5 phytochemicals (ferulic acid, meranzin hydrate, hesperidin, peoniflorin and Senkyunolide) in which each is absorbed into hippocampus and jejunum via polypharmacology including HPA axis, 5-HT, NA, DA et al when 7 agents each was administered respectively; ii.some shared molecules (α2-AR, ghrelin, 5-HT1 and BDNF/p-mTOR) of rat gut-brain axis following forced swimming or treatment simultaneously mediate A&P, respectively supported by strict agonist or antagonist-evidenced experiments. We concluded from above results: i.Shugan guided the discovery of A&P's CSS, fructus aurantii and 5 phytochemials; ii. these holistic agents play A&P role via regulating 4 shared molecules following stress, highlighting depressive or anti-depressive unitied theory involed in pathegenesis and therapeutics.