Day 1 :
Nanjing University of Chinese Medicine, China
Keynote: Shugan clue us to the discovery of shared molecules that mediate anti-depression and prokinetic in stressed rat
Time : 10:00-10:45
Xi Huang has completed his PhD from Fouth Military Medical University in 1995 and postdoctoral studies from Xiyuan Hospital, China Academy of Chinese Medicine Science in 1998 respectively. He is the director and Professor of Institute of TCM-related depressive comorbidity, Nanjing University of Chinese Medicine. He has got 9 funds of National Natural Science Foundations of China. Among > 200 papers as corresponace author, 41 involve in TCM in SCI journals. He is > 10 editorial board members or correspondence reviewer of repute journal. He also is Chairmen of Basic Theory Committee of China Association of Integrated Medicine
The unique challenge of DCWFD (depressive comorbidity with functional dyspepsia, FD) is its unitied theory including shared pathogenesis and therapeutic strategy. The latter inhibition to gut motor by SSRIs result in anti-depressive discontinuance. Surprisedly, Shugan, one of TCM strategies against DCWFD, has been being neglected during past 2200 years until the discovery of its anti-depression and prokinetic (A&P) in 2011. Here, Shugan-treated target is Ganyupixu (ancient disease name of TCM) similar to DCWFD in symptoms. Clinically and experimently it also has been comprehensively and seperately applied in the treatment of depression, FD and DCWFD. From above clues, we advance the hypothesis involed in simultaneous A&P against stress. The evidences for testing hypothesis in stressed rats include: i.simultaneous A&P activities by 7 agents including TCM Chaihu-Shugan-San (it contains 6 herbs of fructus aurantii,et al), fructus aurantii and the related 5 phytochemicals (ferulic acid, meranzin hydrate, hesperidin, peoniflorin and Senkyunolide) in which each is absorbed into hippocampus and jejunum via polypharmacology including HPA axis, 5-HT, NA, DA et al when 7 agents each was administered respectively; ii.some shared molecules (α2-AR, ghrelin, 5-HT1 and BDNF/p-mTOR) of rat gut-brain axis following forced swimming or treatment simultaneously mediate A&P, respectively supported by strict agonist or antagonist-evidenced experiments. We concluded from above results: i.Shugan guided the discovery of A&P's CSS, fructus aurantii and 5 phytochemials; ii. these holistic agents play A&P role via regulating 4 shared molecules following stress, highlighting depressive or anti-depressive unitied theory involed in pathegenesis and therapeutics.
University of Athens, Greece
Keynote: Pythagorean Self-awareness Technique for Stress Management and Self-Empowerment Related to Healthy Lifestyle in Healthy Volunteers: A Pilot Study.
Time : 11:15-12:00
Dr. Christina Darviri is Professor of Prevention and Health Promotion. Since 2008, she has been serving as the co-Scientific director with professor G .Chrousos of the MSc/PhD Program entitled "The Science of Stress and Health Promotion" at the Medical School of the National and Kapodistrian University of Athens, Athens, Greece. She lectures on stress-related nosology, lifestyle and stress, efficient stress management and the overall connection between stress and health promotion. She has published over 50 peer-reviewed articles in the field of stress. She has also supervised over 100 theses on stress, health and disease and published many books.She has been the principal investigator of many research projects, focusing on issues such as healthy longevity and how life style impacts stress resilience, as well as how to effectively auto regulate hypertension through stress management and health promotion. Her latest scientific project is a technique called "Pythagorean Self-awareness for Stress Management, Memory Improvement and Sense of Well-being”.
Coping with stress and making healthy choices become increasingly difficult for individuals with low self-empowerment. The goal of this pilot study was to assess a new technique dubbed "Pythagorean Self-awareness Technique" (PSAT), based on Pythagorean philosophy. This is a mental technique, performed twice per day, with three stages: sequential recall of daily events, primary contemplation on thoughts-emotions related to each event and the critical appraisal of the individual's attitude. A sample of 34 healthy volunteers (13 males, 21 females, mean age: 49, from 23 to 72 years old) attending this program for 8 weeks was assessed. We followed a heuristic approach by measuring various aspects of mental and physical health both prior and after the end of the program. Significant beneficial effects were categorized in terms of d effect sizes: medium (0.3 or below), moderate (0.3-0.5), high (over 0.5). High effect sizes were note for the following measures (in decreasing effect sizes): perceived stress (d=0.78), mental fatigue (d=0.74), negative emotions (d=0.70), sleep disturbances (d=0.68), emotion control (d=0.67), control of anger (d=0.66), self-control (d=0.64), management of self-emotions (d=0.63), scheduled physical exercise (d=0.63), pride (d=0.63), speed of cognitive tasks (d=0.58), cognitive fatigue (d=0.58), sleep onset (d=0.56) depression (d=0.55), self-awareness (d=0.51), daily routine (0.50) and dietary healthy choices (d=0.50). Moderate effect sizes were found for anxiety (d=0.49), guilds (d=0.48), restful sleep (d=0.47) and for systolic blood pressure (d=0.43). In conclusion, PSAT can be validated as a potent technique since it benefits both mental and physical aspects of health.