Genetics of Mood Disorders
Genetics of Mood Disorders is a compelling area of mental health research that explores the hereditary influences underlying conditions such as depression and bipolar disorder. Mood disorders often run in families, indicating a significant genetic component in their development. While no single gene causes these disorders outright, numerous studies suggest that a complex interplay of multiple genes, each contributing a small effect, increases an individual’s vulnerability. Twin, family, and adoption studies consistently demonstrate that the heritability of major depressive disorder (MDD) is approximately 40–50%, while bipolar disorder (BD) shows even higher heritability rates, estimated at 60–85%.Advancements in molecular genetics, especially genome-wide association studies (GWAS), have helped identify specific genetic variations linked to mood disorders.
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